Intrauterine Insemination

 
Intrauterine Insemination (IUI) involves the deposit of prepared sperm into the uterine cavity via a thin, flexible catheter that is passed through the cervix.    
 
There are different types of IUI that are undertaken at CRGH and your consultant will discuss your options fully at consultation. These include:-

IUI is minimally invasive and generally causes no more discomfort than a cervical or PAP smear, however it is not as successful as IVF. 

Natural Cycle Insemination

 
This treatment involves tracking the growth of the follicle/s by ultrasound scan, starting from approximately day ten of the cycle depending on average cycle length.  The ultrasound scans are combined with home ovulation predictor kits.  Once the follicle/s have reached an appropriate size and if there has been no positive ovulation surge detected an injection of hCG (Pregnyl) will be administered to induce ovulation. 
 
The procedure will then occur the following day prior to ovulation commencing.  It is important to be aware that a positive ovulation does not mean that you are currently ovulating. It means that your Lutenising Hormone (LH) is increasing indicating that ovulation will occur within the next twenty-four to forty hours.
 
 

Clomid Combined With IUI

 
This treatment involves taking Clomiphene Citrate (Clomid) tablets in conjunction with the IUI procedure.  Clomid is a tablet that works by increasing the amount and length of Follicle Stimulating Hormone (FSH) production to stimulate follicle growth. These tablets are taken in the evening at the beginning of the cycle.  Follicular tracking scans are then undertaken from approximately day ten of the cycle. The ultrasound scans are combined with home ovulation predictor kits. 
 
Once the follicle/s have reached an appropriate size and if there has been no positive ovulation surge detected an injection of hCG (Pregnyl) will be administered to induce ovulation.  The procedure will then occur the following day prior to ovulation commencing.  It is important to be aware that a positive ovulation does not mean that you are currently ovulating. It means that your Lutenising Hormone (LH) is increasing indicating that ovulation will occur usually within the next twenty-four hours.
 
 

Super-Ovulation IUI

 
This treatment uses Follicle Stimulating Hormone (FSH) administered via subcutaneous injection.  An ultrasound scan is undertaken on day 1, 2, 3 or 4 of the period to determine if there are any cysts present on the ovaries.  If the ovaries are clear and the endometrium is thin, you will see a nurse to learn self-injection. These injections are administered on alternate days. Most patients will have two doses of FSH before returning for a scan to track follicular growth. Subsequent scans are then decided on. 
Once the follicle/s have reached an appropriate size an injection of hCG (Pregnyl) will be administered to induce ovulation.  The IUI procedure will then occur the following day prior to ovulation.
 
 

Ovulation Induction IUI

 
This treatment is most often utilised for patients who have PCOS and irregular periods that are most likely not ovulating regularly. An ultrasound scan is performed to assess whether the endometrium is thin and the ovaries are clear of cysts.  Then a low dose Follicle Stimulating Hormone (FSH) is administered via subcutaneous injection on a daily basis.
 
The first ultrasound scan is usually performed after seven days with subsequent scans then being decided on.  Once the follicle/s have reached an appropriate size an injection of hCG (Pregnyl) will be administered to induce ovulation.  The IUI procedure will then occur the following day prior to ovulation.
 
 
The Centre for Reproductive and Genetic Health (CRGH)
The New Wing - Eastman Dental Hospital
256 Gray's Inn Road - London WC1X 8LD
t: 020 7837 2905 w: www.crgh.co.uk